Uma Thurman

Sissy Hankshaw

Lorraine Bracco

Delores Del Ruby

Pat Morita

The Chink

Angie Dickinson

Miss Adrian

Keanu Reeves

Julian Gitche

John Hurt

The Countess

Rain Phoenix

Bonanza Jellybean

Ed Begley Jr.

Rupert

Carol Kane

Carla

Sean Young

Marie Barth

Crispin Glover

Howard Barth

Roseanne Barr

Madame Zoe

Buck Henry

Dr. Dreyfus

Grace Zabriskie

Mrs. Hankshaw

Treva Jeffryes

Young Sissy

Ken Kesey

Sissy's Daddy

Ken Babbs

Sissy's Uncle

Allen Arnold

Lionel

Victoria Williams

Cowgirl Debbie

Heather Graham

Cowgirl Heather

Judy Robinson

Cowgirl Gloria

Betsy Roth

Cowgirl Mary

Arlene Wewa

Big Red

Heather Hershey

Cowgirl Donna

Dee Fowler

Cowgirl Kym

Udo Kier

Commercial Director

Wade Evans

Cameraman

Tom Peterson

Crewman

Alexa D'Avalon

Rubber Rose Bird Expert

Eric Hull

White House Undersecretary

Oliver Kirk

Sheriff

Joe Ivy

FBI Director

Greg McMickle

FBI Agent

Lin Shaye

Rubber Rose Maid

Chel White

Brain Surgeon

Molly Little

Salsa Singer

Scott Patrick Green

Pilgrim Man

Suzanne Solgot

Pilgrim Woman

Michael Parker

Pilgrim Driver

William S. Burroughs

Self

Sherry Alps

Cowgirl

Eliza Butterfly

Cowgirl

Boo Connolly

Cowgirl

Christie Flenniken

Cowgirl

Stacey Hyder

Cowgirl

Tina Knaggs

Cowgirl

Tom Robbins

Narrator (voice)

Roger Bowen

Naturalist (uncredited)

Edward James Olmos

Musician at Barbecue (uncredited)