Simon Baker

Roderick Blank

Winona Ryder

Death Nell / Gillian De Raisx (#101)

Leslie Bibb

Dr. Miranda Storm

Mindy Cohn

Trixie

Julie Bowen

Fiona Wormwood (#29)

Dash Mihok

Lester

Neil Flynn

Zack

Patton Oswalt

Fred

Frances Fisher

Hope Hartlight (#80)

Robert Wisdom

Alpha

Marshall Bell

Victor Rose III

Sophie Monk

Cynthia Rose (#31)

Tanc Sade

Beta

Natassia Malthe

Bambi (#63)

Pollyanna McIntosh

Thumper (#64)

Rob Benedict

Bow-Tie Bob

Jessica Kiper

Precious / Carlotta Valdes (#30)

Winter Ave Zoli

Alexis De Large (#37)

Cindy Pickett

Roderick's Mother

Candice Coke

Greta Samsa (#32)

Christopher Stapleton

Terry Fenchel (#71)

Retta

Ethel Walters (#100)

Corinne Reilly

Lizzie

Amanda Walsh

Stewardess Kathleen

Indira Varma

Devon Sever

Bryan Okes

Buzzkilling Bodyguard

Zachary Gordon

Barbecue Brat

Skyler James Sandak

Roderick Blank Jr.

Nicole Bilderback

Dr. Mirabella Stone (#66)

Keram Malicki-Sánchez

Master Bitchslap

Siobhan Flynn

Esther Fenchel

Bryan Ross

Bachelor Party Buddy (as Brian Ross)

Greg Travis

Vulgar Newsstand Vendor

David Magidoff

Video Store Geek

Buckley Norris

Club Owner (as Buckley Francis Norris)

Tarek Bishara

Malcolm the Bartender (as Thom Bishops)

William Caploe

Barista Bill

Patrick Leo Holland

Wonderful Waiter

Ryan Cutrona

Officer Krupke

Cean Okada

Edwina Massey (#67)

Lauren Michelle Hill

Amberette

David Bortolucci

Agent

Annie Kehoe

Death Nell Wannabee

Kacie Borrowman

Vixen Blitzen (#69)

Elisha Skorman

Helena Hartford (uncredited)