James Mason

Dr. John Polidori

Leonard Whiting

Victor Frankenstein

David McCallum

Dr. Henri Clerval

Jane Seymour

Agatha/Prima

Nicola Pagett

Elizabeth Fanschawe

Michael Sarrazin

The Creature

Michael Wilding

Sir Richard Fanshawe

Clarissa Kaye-Mason

Lady Fanschawe (as Clarissa Kaye)

Julian Barnes

Young Man

Agnes Moorehead

Mrs. Blair

Margaret Leighton

Francoise DuVal

Ralph Richardson

Mr. Lacey

John Gielgud

Chief Constable

Tom Baker

Sea Captain

Arnold Diamond

Passenger in Coach

Yootha Joyce

Hospital Matron

Peter Sallis

Priest

Dallas Adams

Felix

Derek Deadman

1st Seaman (uncredited)

Paddy Joyce

1st Helper (uncredited)

Norman Rossington

Seaman (uncredited)

Elizabeth Spender

Ballroom Guest (uncredited)

Jeremy Young

2nd Helper (uncredited)