John Travolta

James

Kirstie Alley

Mollie

Olympia Dukakis

Rosie

George Segal

Albert

Abe Vigoda

Grandpa

Bruce Willis

Mikey (voice)

Twink Caplan

Rona

Jason Schaller

Mikey

Jaryd Waterhouse

Mikey

Jacob Haines

Mikey

Christopher Aydon

Mikey

Joy Boushel

Melissa

Don S. Davis

Dr. Fleischer

Louis Heckerling

Lou

Brenda Crichlow

Secretary

Andrea Mann

Salesgirl

Douglas Tuck

Cab Stealer

Alex Bruhanski

Street Worker

Casey Grant

Admitting Clerk

Oscar B. Ramos

Hospital Worker

Aurelio Dinunzio

Orderly

Jeff Irvine

Admitting Doctor

Shirley Barclay

Nurse

William B. Davis

Drug Doctor

David Berner

Mr. Impatience

Jerry Wasserman

Mr. Anal

Daliah Novak

Carrie

Zena Darawalla

Lupe

Nicholas Rice

Harry

Neal Israel

Mr. Ross

Blu Mankuma

Director

William Britos

Home Orderly

Dee Jay Jackson

Burly Orderly

Ida Berner

Lady

Bea Cartmell

Lady

Eleanor Maines

Lady

Mollie Heckerling

Little Girl

Ryan McIntosh

Little Boy

Gerry Bean

Pilot Friend

Deryl Hayes

Pilot Friend

Enid Saunders

Ester

Nicole Stevens

Silly Baby

Christy Smith

Baby Megan

Sabrina Bailey

Sand Box Baby

Farah Abassi

Chatting Baby

Amber Brownmiller

Blowing Kiss Baby

Ariel Perryman

Nursery Baby

Nigel John Crowe

Nursery Baby

Michael Joseph Materi

Nursery Baby

Joan Rivers

Julie (voice) (uncredited)