Paul Reubens

Pee-wee Herman

E. G. Daily

Dottie

Mark Holton

Francis

Diane Salinger

Simone

Judd Omen

Mickey

Irving Hellman

Mr. Crowtrey

Monte Landis

Mario

Damon Martin

Chip

Alice Nunn

Large Marge

David C. Glasser

BMX Kid

Gregory Brown

BMX Kid

Daryl Keith Roach

Chuck

Bill Cable

Policeman #1

Peter Looney

Policeman #2

Starletta DuPois

Sgt. Hunter

Professor Toru Tanaka

Butler

Ed Herlihy

Mr. Buxton

Ralph Seymour

Francis' Accomplice

Lou Cutell

Amazing Larry

Raymond Martino

Gang Member

Erica Yohn

Madam Ruby

Bill W. Richmond

Highway Patrolman

Ed Griffith

Trucker

Simmy Bow

Man in Diner

Jon Harris

Andy

Carmen Filpi

Hobo Jack

Jan Hooks

Tina

John Moody

Bus Clerk

John O'Neill

Cowboy #1

Alex Sharp

Cowboy #2

Chester Grimes

Biker #1

Luis Contreras

Biker #2

Lonnie Parkinson

Biker #3

Howard Hirdler

Biker #4

Cassandra Peterson

Biker Mama

Jason Hervey

Kevin Morton

Bob McClurg

Studio Guard

John Paragon

Movie Lot Actor

Susan Barnes

Movie Lot Actress

Zachary Hoffman

Director

Lynne Marie Stewart

Mother Superior

George Sasaki

Japanese Director

Richard Brose

Tarzan

Drew Seward

Kid #1

Brett Fellman

Kid #2

Bob Drew

Fireman

John Gilgreen

Policeman at Pet Shop

Noreen Hennessey

Reporter

Phil Hartman

Reporter

Michael Varhol

Photographer

David Rothenberg

Hobo

Patrick Cranshaw

Hobo

Sunshine Parker

Hobo

Gilles Savard

Pierre

James Brolin

"P. W."

Morgan Fairchild

"Dottie"

Tony Bill

Terry Hawthorne

Dee Snider

Self

Milton Berle

Self (uncredited)

Terry Bolo

Biker Chick (uncredited)

Tim Burton

Thug in Alley (uncredited)

Manuel Benitez

BMX Kid #0

Bill Baker

Dancing Blonde Beach Boy / Bellboy (uncredited)