Ray Romano

Manfred 'Manny' (voice)

John Leguizamo

Sid (voice)

Denis Leary

Diego (voice)

Goran Višnjić

Soto (voice)

Jack Black

Zeke (voice)

Cedric the Entertainer

Rhino (voice)

Stephen Root

Rhino / Start (voice)

Diedrich Bader

Saber-Toothed Tiger (voice)

Alan Tudyk

Saber-Toothed Tiger / Freaky Mammal (voice)

Lorri Bagley

Female Sloth (voice)

Jane Krakowski

Female Sloth (voice)

Peter Ackerman

Dodo / Freaky Mammal (voice)

P.J. Benjamin

Dodo (voice)

Josh Hamilton

Dodo / Aardvark (voice)

Denny Dillon

Glypto (voice)

Mitzi McCall

Glypto (voice)

Tara Strong

Start (voice)

Chris Wedge

Dodo / Scrat (voice)

Kristen Johnston

Sylvia (voice) (uncredited)

Darin De Paul

Additional Voices (voice) (uncredited)

Dann Fink

Dodo (voice) (uncredited)

Patrick Pinney

Various Mammals (uncredited)

Phil Proctor

Various Mammals (uncredited)