Kevin Hart

George Beard (voice)

Thomas Middleditch

Harold Hutchins (voice)

Ed Helms

Mr. Krupp / Captain Underpants (voice)

Nick Kroll

Professor Poopypants (voice)

Jordan Peele

Melvin (voice)

Kristen Schaal

Edith (voice)

DeeDee Rescher

Ms. Ribble (voice)

Brian Posehn

Mr. Rected (voice)

David Soren

Tommy (voice)

Mel Rodriguez

Mr. Fyde (voice)

Susan Fitzker

Ms. Dayken (voice)

Lynnanne Zager

George's Mom (voice)

Tiffany Lauren Bennicke

Sad Girl (voice)

James Ryan

Mime (voice)

Leslie David Baker

Officer McPiggly (voice)

Sugar Lyn Beard

Goodie Two-Shoes Girl (voice)

Lesley Nicol

Nobel Moderator (voice)

Chris Miller

Nobel Audience Member (voice)

Coco Soren

Balloon Girl (voice)