E. G. Daily

Tommy Pickles (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Cheryl Chase

Angelica Pickles (voice)

Susan Sarandon

Coco LaBouche (voice)

John Lithgow

Jean-Claude (voice)

Tara Strong

Dil Pickles (voice)

Kath Soucie

Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell

Drew Pickles / Chaz Finster, Sr. (voice)

Cree Summer

Susie Carmichael (voice)

Tress MacNeille

Charlotte Pickles (voice)

Debbie Reynolds

Lulu Pickles (voice)

Joe Alaskey

Grandpa Lou Pickles (voice)

Mako

Mr. Yamaguchi (voice)

Tim Curry

Sumo Singer (voice)

Julia Kato

Kira Watanabe-Finster (voice)

Billy West

Sumo Singer (voice)

Dionne Quan

Kimi Watanabe-Finster (voice)

Melanie Chartoff

Didi Pickles (voice)

Casey Kasem

Wedding DJ (voice)

Phil Proctor

Howard DeVille (voice)

Lisa McClowry

Princess (voice)

Dan Castellaneta

Priest (voice)

Roger Rose

Finster Wedding DJ (voice)

Kevin Michael Richardson

Sumo Singer (voice)

Jack Riley

Stu Pickles (voice)

Charlie Adler

Inspector (voice)

Braden Wright

Café Owner (voice)

Charles Fathy

Photographer (voice)

Margaret Smith

Stewardess (voice)

Phillipe Simon

Animatronic Bus Driver (voice)

Paul Demeyer

Dogcatcher / Street Cleaner (voice)

Richard Michel

French Worker (voice)

Philip Benichou

Ninja (voice)

Hannah Makragelidis

Pre-School Kid (voice)

Shannon Stephens

Pre-School Kid (voice)

Ben Sunderland

Pre-School Kid (voice)