Fredric March

Christopher Columbus

Florence Eldridge

Queen Isabella

Francis L. Sullivan

Francisco de Bobadilla

Kathleen Ryan

Beatriz Enriquez de Arana

Derek Bond

Diego de Arana

Nora Swinburne

Joanna de Torres

Abraham Sofaer

Luis de Santangel

Linden Travers

Beatriz de Peraza

James Robertson Justice

Martin Alonso Pinzon

Dennis Vance

Francisco Pinzon

Richard Aherne

Vicente Yañez Pinzon

Felix Aylmer

Father Perez

Francis Lister

King Ferdinand

Edward Rigby

Pedro

Niall MacGinnis

Juan de la Cosa

Ralph Truman

Captain

Ronald Adam

Talavera

Guy Le Feuvre

Admiral

Lyn Evans

Lope

David Cole

Diego Columbus - Columbus' Son

Hugh Pryse

Almoner

Stuart Lindsell

Prior

Valentine Dyall

Narrator (voice)

Thelma Grigg

Lady in waiting (uncredited)

Anthony Steel

Messenger (uncredited)