Antonio Banderas

El Mariachi

Johnny Depp

CIA Agent Jeffrey Sands

Cheech Marin

Belini

Salma Hayek Pinault

Carolina

Mickey Rourke

Billy Chambers

Willem Dafoe

Armando Barillo

Eva Mendes

CIA Agent Ajedrez

Danny Trejo

Cucuy

Rubén Blades

Jorge, Retired FBI Agent

Enrique Iglesias

Lorenzo

Marco Leonardi

Fideo

Troy Robinson

Romero

Gerardo Vigil

General Marquez

Pedro Armendáriz Jr.

President of Mexico

Julio Oscar Mechoso

Nicholas, Presidential Advisor

Tito Larriva

Cab Driver

Miguel Couturier

Dr. Guevera

Tony Valdes

Chicle Boy

José Luis Avendaño

Alvaro

Rodolfo De Alexandre

Omar

Natália Torres

El Mariachi's Daughter

Steve Constancio

Right Hand

Ermahn Ospina

Qui-Que

Luz María Rojas

Pistolera

Mario Simon

Cook

Bernard Hacker

Blascoe

Cecilia Tijerina

Waitress

Carola Vázquez

Hospital Administrator

René Gatica

Chief Federale

Silvia Santoyo

Bachelorette

Juan Pablo Llaguno

Bull Fighter

Ignacio Torre

Teacher

Rojo Grau

Manny

Jorge Becerril

Taco

Víctor Carpinteiro

Left Nut

Dagoberto Gama

Que Pasa

Thomas Rosales Jr.

Bartender with Gun (uncredited)

Khristian Lupo

Soldier (uncredited)