Keith Ferguson

Megamind (voice)

Laura Post

Roxanne Ritchi (voice)

Josh Brener

OI' Chum (voice)

Maya Tuttle

Keiko Morita (voice)

Emily Tuñon

Lady Doppler (voice)

Talon Warburton

Lord Nighty-Knight (voice)

Scott Adsit

Pierre Pressure (voice)

Chris Sullivan

Behemoth (voice)

Tony Hale

Mel / Mr. Donut / TV Announcer (voice)

Adam Lambert

Machiavillain (voice)

Jeanine Mason

Christina Christo / Hostess (voice)

Michael Beattie

Eccentric Eddie (voice)

Eric Fogel

Polly 227 (voice)

Todd Haberkorn

Big King Fish (voice)

Eric Murphy

Blue Mackerel (voice)

Joey Rudman

Red Snapper (voice)

Roger Craig Smith

Mayor (voice)

Carlos Alazraqui

Additional Voices (voice)

Eric Bauza

Additional Voices (voice)

Kimberly Brooks

Additional Voices (voice)