Bill Pullman

George Bailey

Penelope Ann Miller

Mary Hatch Bailey

Nathan Lane

Clarence

Martin Landau

Pa Bailey / Mr. Potter

Sally Field

Mrs. Bailey / Narrator

Joe Mantegna

Joseph / Nick

Christian Slater

Harry Bailey / Sam Wainwright

Jerry Van Dyke

Uncle Billy

Robert Guillaume

Mr. Gower

Carol Kane

Cousin Tilly / Mrs. Hatch

Bronson Pinchot

Mr. Carter

Dan Lauria

Bert

Craig Sheffer

Ernie Bishop / Ed / Bridgekeeper

Armelia McQueen

Mrs. Thompson

Ryan Slater

Young George Bailey / Peter Bailey

Tina Majorino

Janie Bailey

Myles Jeffrey

Tommy Bailey

Mae Whitman

Zuzu Bailey

Casey Kasem

Radio Announcer