Eddie Murphy

Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins

Janet Jackson

Denise

Larry Miller

Dean Richmond

John Ales

Jason

Richard Gant

Denise's Father

Anna Maria Horsford

Denise's Mother

Melinda McGraw

Leanne Guilford

Jamal Mixon

Ernie Klump, Jr.

Gabriel Williams

Issac

Chris Elliott

Restaurant Manager

Duffy Taylor

Restaurant Trainee

Earl Boen

Dr. Knoll

Nikki Cox

Bright Student

Freda Payne

Claudine

Sylvester Jenkins

Old Willie

Wanda Sykes

Chantal

George King

Stripper

Charles Walker

Preacher

Enya Flack

Bridesmaid

Rainell Saunders

Bridesmaid

Andrea C. Robinson

Party Guest / Bridesmaid

Kym Whitley

Party Guest

Selma Stern

Mrs. Dudikoff

Julia Schultz

Receptionist

Barry W. Blaustein

Man in Bathroom

David Sheffield

Man in Bathroom

Ralph Drischell

Zeke

Myles Mason

Baby Buddy

Jeffrey Michael Freeman

Baby Buddy

Maurice Colquitt

Baby Buddy

Bill Applebaum

Boardroom Member

Harry S. Murphy

Boardroom Member

Tom Jourden

Guy in Elevator

Shawnette Heard

Dancer

Kelly Konno

Dancer

Laurie Sposit

Dancer

Nadine Ellis

Dancer

Kevin Michael Mondane

Buddy at 15

Viola Kates Stimpson

Sweet Old Lady with Dog

Naomi Morales

Buxom Student

Kente Scott

Fraternity Student

Justin Urich

Lecture Student

Sonya Eddy

Heavyset Woman

James D. Brubaker

Krusty Reporter

Richie Palmer

Cab Driver

Charles Napier

Four Star General

Steve Kehela

Scientist

Miguel A. Núñez Jr.

Scientist

Richard Saxton

Newscaster

Peter Segal

Scared Popcorn Man

William Kerr

Scared Popcorn Man

Michael Ewing

Scared Hot Dog Vendor

Nikki Segal

Scared Little Girl

Kathleen Freeman

Denise's Nosy Neighbor (uncredited)