Shirley MacLaine

Aurora Greenway

Debra Winger

Emma Greenway Horton

Jack Nicholson

Garrett Breedlove

Danny DeVito

Vernon Dahlart

Jeff Daniels

Flap Horton

John Lithgow

Sam Burns

Lisa Hart Carroll

Patsy Clark

Betty King

Rosie Dunlop

Huckleberry Fox

Teddy Horton

Troy Bishop

Tommy Horton

Shane Serwin

Younger Tommy Horton

Megan Morris

Melanie Horton

Tara Yeakey

Baby Melanie

Norman Bennett

Edward Johnson

Jennifer Josey

Young Emma

Kate Charleson

Janice

Tom Wees

Dr. Budge

Paul Menzel

Dr. Maise

F. William Parker

Doctor

Amanda Watkins

Meg

Buddy Gilbert

Dr. Ratcher

David Wohl

Phil

Shelley K. Nielsen

Nurse

Bette Croissant

Nurse

Charles Beall

Rudyard's Employer

Lelise Folse

Doris

Sharisse Baker-Bernard

Lee Anne

Judy Dickerson

Checkout Girl

Devon O'Brien

Lizbeth

Dana Vance

Victoria

Alexandra O'Karma

Jane

Nancy Mette

Woman at Party

Holly Holmberg Brooks

T.J.

Lear Levin

Jack Stern

Albert Brooks

Rudyard Greenway (voice)

Lanier Whilden

Patsy's Mother

Helen Stauffer

Flap's Secretary

Barbara Balik

Woman

Michelle Watkins

Woman

John C. Conger

Moving Man

Sandra Newkirk

Mrs. Johnson

Elaine McGown

Herself

Mary Kay Place

Doris (voice)