Laura Linney

Dr. Karen Ross

Dylan Walsh

Dr. Peter Elliot

Ernie Hudson

Captain Monroe Kelly

Tim Curry

Herkermer Homolka

Grant Heslov

Richard

Joe Don Baker

R.B. Travis

Misty Rosas

Amy

Mary Ellen Trainor

Moira

Stuart Pankin

Boyd

Carolyn Seymour

Eleanor Romy

Romy Rosemont

Assistant

Lorene Noh

Amy

James Karen

College President / Elliot's Boss

Bill Pugin

William

Lawrence T. Wrentz

Prof. Arliss Wender

Robert Almodovar

Rudy, TraviCom Security

Kathleen Connors

Sally

Joel Weiss

TraviCom Operator

John Hawkes

Bob Driscoll

Peter Jason

Mr. Janus

Jimmy Buffett

727 Pilot

James Paradise

Transport Worker #1

William John Murphy

Transport Worker #2

Thom Barry

Samahani

Ayo Adejugbe

African Airport Guard

Kevin Grevioux

Roadblock Officer

Karara Muhoro

Roadblock Soldier

Darnell Suttles

Hospital Interrogator

Michael Chinyamurindi

Claude from Mombasa

Willie Amakye

Lead Porter

Malang

Porter

Jay Speed Forney

Porter

Shelton Mack

Porter

David Mungai

Porter

Anthony Mutune

Porter

Sylvester Mwangi

Porter

Les Robinson

Porter

Nelson Shalita

Porter

E.J. Callahan

DC-3 Pilot

Guy Toley

DC-3 Co-Pilot

Jackson Gitonga

Mizumu Tribesman

Andrew Kamuyu

Mizumu Tribesman

Fidel Bateke

Witch Doctor

Shayna Fox

Amy (voice)

Bruce Campbell

Charles Travis

Taylor Nichols

Jeffrey Weems

Adewale Akinnuoye-Agbaje

Kahega

David Anthony

Gorilla

Brian La Rosa

Gorilla

John Munro Cameron

Gorilla (as John Cameron)

John Alexander Lowe

Gorilla

Jay Caputo

Gorilla

Garon Michael

Gorilla

Peter Elliott

Gorilla

David St. Pierre

Gorilla

Eldon Jackson

Gorilla

Philip Tan

Gorilla

Nicholas Kadi

Gorilla

Christopher 'Critter' Antonucci

Gorilla

Loren Cross

Ghost Tribe Member (Uncredited)

Chris Dupre

Tribe Member (Uncredited)

Delroy Lindo

Captain Wanta (Uncredited)

Joe Pantoliano

Eddie Ventro (Uncredited)

Paul Speaks

Scientist (Uncredited)